Globalide 100 (Habanolide)

Synthetic Ingredient Overview

• 🏭 Manufacturer: Symrise

• 🔎 IUPAC Name: (12E)-oxacyclohexadec-12-en-2-one

• 🧪 Synonyms: Globalide® 100, Habanolide, Oxacyclohexadecenone, Musk Habanolide

• 🧬 Chemical Formula: C₁₅H₂₆O₂

• 📂 CAS N°: 34902-57-3

• 📘 FEMA: Not applicable

• ⚖️ Molecular Weight: 238.37 g/mol

• 📝 Odor Type: Musk

• 📈 Odor Strength: Medium, extremely persistent (≥2 weeks on blotter)

• 👃🏼 Odor Profile: Elegant, soft musk; powdery, waxy, with metallic “hot iron” nuance

• ⚗️ Primary Uses: Fine fragrance musky bases, floral blends, masculine woods, skin musks

• 🧴 Appearance: Colorless to pale yellow oily liquid

What is Globalide® 100 (Habanolide)?

Globalide® 100 is the Symrise trade name for Habanolide, an unsaturated macrocyclic musk belonging to the family of 16-membered lactones (specifically an enone-lactone). It represents the (12E)-stereoisomer of oxacyclohexadec-12-en-2-one and was historically discovered as an impurity in Exaltolide synthesis — later isolated and developed for its unique olfactory performance.

Unlike saturated macrocyclic musks (e.g., muscone or exaltolide), Habanolide’s double bond introduces spatial asymmetry and dynamic diffusion, improving sillage and skin radiance. Its unsaturation makes it brighter and more structurally diffusive while retaining macrocyclic warmth and softness.

Olfactory Profile and Perfumery Applications

Globalide® 100 has a characteristically clean, soft musk odor that is elegant and versatile. The powdery sweetness is complemented by a waxy, slightly metallic quality reminiscent of hot iron or polished fabric. Despite moderate impact, its longevity is exceptional — persisting for two weeks or more on paper.

Key uses include:

• Skin musks: Offers elegant, intimate softness with clean persistence

• Woody-musk bases: Enhances masculine accords with metallic dryness

• Floral musks: Supports peony, jasmine, or violet with warm powdery body

• Modern fougères and colognes: Balances citrus with smooth white musks

Its clean, non-animalic character allows high usage levels without dominating a formula.

Industrial and Technical Uses

Globalide® 100 is used in both fine fragrance and functional categories:

• Body lotions and creams: Delivers long-lasting muskiness and enhances base diffusion

• Shampoos and fabric conditioners: Retains fragrance on substrates for prolonged freshness

• Air care and scented laundry products: Musk presence remains after evaporation or rinse-off

While primarily a perfumery raw material, it is not used in food, pharma, or tobacco products due to its high molecular weight and lack of volatility in flavor matrices.

Regulatory and Safety Overview

• IFRA: No specific restrictions under IFRA 51st Amendment

• EU Allergens: Not listed among the 26 declarable fragrance allergens

• FEMA GRAS: Not applicable for flavor use

• ECHA (REACH): Registered under REACH; no hazard classification

• Toxicology: Non-sensitizing, low toxicity by dermal and inhalation exposure

• Environmental Profile: Not classified as PBT or vPvB; biodegradable in fragrance-use concentrations

✅ Approved for unrestricted use in fragrance compositions across all categories.

Sources

• Symrise Technical Documentation – Globalide® 100

• NCBI PubChem Summary – CID 9856149, (12E)-Oxacyclohexadec-12-en-2-one

• Scentspiracy Analysis Archive – Fulvio Ciccolo (2022)

• Fragrance Chemistry Literature on Macrocyclic and Unsaturated Musks

• IFRA Standards – 51st Amendment

• ECHA Substance Database – CAS 34902-57-3